Efficacia scientificamente provata

La formulazione di CistiDyn® si è basata sulla ricerca di micronutrienti e sostanze bioattive per le quali vi sono prove di efficacia, in linea con le evidenze pubblicate su PubMed.
La sinergia tra le sostanze bioattive selezionate permette di potenziare l’attività d’azione della miscela e di agire con un’azione di protezione a 360 gradi.
Tè verde e cranberry contribuiscono al drenaggio dei liquidi corporei e alla funzionalità delle vie urinarie. La formulazione è stata ottimizzata con l’aggiunta di D-mannosio, 2’-fucosillattosio, quercetina e vitamina C.
Di seguito potete trovare una bibliografia selezionata che riporta i principali studi clinici, revisioni sistematiche e review sull’utilizzo di micronutrienti e sostanze bioattive nelle donne con infezioni ricorrenti delle vie urinarie.

Bibliografia

1. Silverman JA, Schreiber HLt, Hooton TM, et al. From physiology to pharmacy: developments in the pathogenesis and treatment of recurrent urinary tract infections. Curr Urol Rep 2013; 14: 448–456.
2. Foxman B and Brown P. Epidemiology of urinary tract infections: transmission and risk factors, incidence, and costs. Infect Dis Clin North Am 2003; 17: 227–241.
3. Nosseir SB, Lind LR and Winkler HA. Recurrent uncomplicated urinary tract infections in women: a review. J Womens Health (Larchmt) 2012; 21: 347–354.
4. Kodner CM and Thomas Gupton EK. Recurrent urinary tract infections in women: diagnosis and management. Am Fam Physician 2010; 82: 638–643.
5. Hooton TM and Gupta K. Recurrent simple cystitis in women, 2019, https://www.uptodate.com/contents/recurrent-simple-cystitis-in-women/contributors#!
6. Gupta K and Trautner BW. Diagnosis and management of recurrent urinary tract infections in non-pregnant women. BMJ 2013; 346: f3140.
7. Albert X, Huertas I, Pereiro II, et al. Antibiotics for preventing recurrent urinary tract infection in non-pregnant women. Cochrane Database Syst Rev 2004: CD001209.
9. European Association of Urology (EAU) Guidelines on urological infections, 2014 (updated 6 June 2014), http://www.uroweb.org/fileadmin/EAUN/guidelines/Extended_guidelines_GL_2014_final_April.pdf
10. Nickel JC, Costerton JW, McLean RJ, et al. Bacterial biofilms: influence on the pathogenesis, diagnosis and treatment of urinary tract infections. J Antimicrob Chemother 1994; 33(Suppl. A): 31–41.
11. Delcaru C, Alexandru I, Podgoreanu P, et al. Microbial biofilms in urinary tract infections and prostatitis: etiology, pathogenicity, and combating strategies. Pathogens 2016; 5: 65. Murina et al. 5
13. Soto M. Importance of biofilms in urinary tract infections: new therapeutic approaches. Adv Biol 2014; Article ID 543974: 13 pages. DOI: 10.1155/2014/543974.
14. Komesu YM, Dinwiddie DL, Richter HE, et al. Defining the relationship between vaginal and urinary microbiomes. Am J Obstet Gynecol 2020; 222: 154.e151–154.e110.
17. Harmidy K, Tufenkji N and Gruenheid S. Perturbation of host cell cytoskeleton by cranberry proanthocyanidins and their effect on enteric infections. PLoS One 2011; 6: e27267.
18 Raditic DM. Complementary and integrative therapies for lower urinary tract diseases. Vet Clin North Am Small Anim Pract. 2015 Jul;45(4):857-78. doi: 10.1016/j.cvsm.2015.02.009. Epub 2015 Mar 31. PMID: 25838155.
19. Andres S, Pevny S, Ziegenhagen R, Bakhiya N, Schäfer B, Hirsch-Ernst KI, Lampen A. Safety Aspects of the Use of Quercetin as a Dietary Supplement. Mol Nutr Food Res. 2018 Jan;62(1). doi: 10.1002/mnfr.201700447
20. D'Andrea G. Quercetin: A flavonol with multifaceted therapeutic applications? Fitoterapia. 2015 Oct;106:256-71. doi: 10.1016/j.fitote.2015.09.018. Epub 2015 Sep 21. PMID: 26393898.
21. Schiavi MC, Porpora MG, Vena F, Prata G, Sciuga V, D'Oria O, Di Tucci C, Savone D, Aleksa N, Giannini A, Nusiner MP, Zullo MA, Muzii L, Benedetti Panici P. Orally Administered Combination of Hyaluronic Acid, Chondroitin Sulfate, Curcumin, and Quercetin in the Prevention of Postcoital Recurrent Urinary Tract Infections: Analysis of 98 Women in Reproductive Age After 6 Months of Treatment. Female Pelvic Med Reconstr Surg. 2019 Jul/Aug;25(4):309-312. doi: 10.1097/SPV.0000000000000560. PMID: 29389678.
22. Beerepoot M, Geerlings S. Non-Antibiotic Prophylaxis for Urinary Tract Infections. Pathogens. 2016 Apr 16;5(2):36. doi: 10.3390/pathogens5020036. PMID: 27092529; PMCID: PMC4931387.
23. Geerlings SE, Beerepoot MA, Prins JM. Prevention of recurrent urinary tract infections in women: antimicrobial and nonantimicrobial strategies. Infect Dis Clin North Am. 2014 Mar;28(1):135-47. doi: 10.1016/j.idc.2013.10.001. Epub 2013 Dec 7. PMID: 24484580.
24. Gill CM, Hughes MA, LaPlante KL. A Review of Nonantibiotic Agents to Prevent Urinary Tract Infections in Older Women. J Am Med Dir Assoc. 2020 Jan;21(1):46-54. doi: 10.1016/j.jamda.2019.04.018. Epub 2019 Jun 18. PMID: 31227473.
25. Palmeira P, Carneiro-Sampaio M. Immunology of breast milk. Rev Assoc Med Bras (1992). 2016 Sep;62(6):584-593. doi: 10.1590/1806-9282.62.06.584. PMID: 27849237.
26. Ballard O, Morrow AL. Human milk composition: nutrients and bioactive factors. Pediatr Clin North Am. 2013 Feb;60(1):49-74. doi: 10.1016/j.pcl.2012.10.002. PMID: 23178060; PMCID: PMC3586783.
27. Morozov V, Hansman G, Hanisch FG, Schroten H, Kunz C. Human Milk Oligosaccharides as Promising Antivirals. Mol Nutr Food Res. 2018 Mar;62(6):e1700679. doi: 10.1002/mnfr.201700679. Epub 2018 Mar 1. PMID: 29336526.
28. Kyriakides R, Jones P, Somani BK. Role of D-Mannose in the Prevention of Recurrent Urinary Tract Infections: Evidence from a Systematic Review of the Literature [published online ahead of print, 2020 Sep . Eur Urol Focus. 2020;S2405-4569(20)30263-7. doi:10.1016/j.euf.2020.09.004
29. Luís Â, Domingues F, Pereira L. Can Cranberries Contribute to Reduce the Incidence of Urinary Tract Infections? A Systematic Review with Meta-Analysis and Trial Sequential Analysis of Clinical Trials. J Urol. 2017;198(3):614-621. doi:10.1016/j.juro.2017.03.078
30. Memariani H, Memariani M, Ghasemian A. An overview on anti-biofilm properties of quercetin against bacterial pathogens. World J Microbiol Biotechnol. 2019;35(9):143. Published 2019 Sep 6. doi:10.1007/s11274-019-2719-5
31. De Nunzio C, Bartoletti R, Tubaro A, Simonato A, Ficarra V. Role of D-Mannose in the Prevention of Recurrent Uncomplicated Cystitis: State of the Art and Future Perspectives. Antibiotics (Basel). 2021 Apr 1;10(4):373. doi: 10.3390/antibiotics10040373. PMID: 33915821; PMCID: PMC8066587.
32. Noormandi A, Dabaghzadeh F. Effects of green tea on Escherichia coli as a uropathogen. J Tradit Complement Med. 2014 Dec 16;5(1):15-20. doi: 10.1016/j.jtcme.2014.10.005. PMID: 26151004; PMCID: PMC4488178.
33. Kheirabadi Z, Mehrabani M, Sarafzadeh F, Dabaghzadeh F, Ahmadinia N. Green tea as an adjunctive therapy for treatment of acute uncomplicated cystitis in women: A randomized clinical trial. Complement Ther Clin Pract. 2019 Feb;34:13-16. doi: 10.1016/j.ctcp.2018.10.018. Epub 2018 Oct 30. PMID: 30712716.
34. Ochoa-Brust GJ, Fernández AR, Villanueva-Ruiz GJ, Velasco R, Trujillo-Hernández B, Vásquez C. Daily intake of 100 mg ascorbic acid as urinary tract infection prophylactic agent during pregnancy. Acta Obstet Gynecol Scand. 2007;86(7):783-7. doi: 10.1080/00016340701273189. PMID: 17611821.